Active sites in Switzerland: Geneva-HUG, Lausanne-CHUV, Zurich, Bern
Study duration : 8 years
Start 2009, End : 2018
Property/Sponsor: HUG

Information program aimed at improving prevention and reducing the chances of recurrence for any patient hospitalized following an acute coronary syndrome and evaluating its impact through a study.

Active sites in Switzerland: HUG, CHUV, Inselspital, Basel, Liestal
Study duration : ~ 3 years
Start in Geneva : september 2020
Property: Novartis Pharmaceuticals

Clinical trial to assess the impact of lowering Lp (a) on major cardiovascular events in patients with a history of cardiovascular disease.

Active sites in Switzerland: Geneva-HUG, Bern-HUB, Lugano-Cardiocentro-Ticino, Zurich-HUZ
Start : january 2015
End : september 2021
Property: Université de Zurich, Swiss National Science Foundation, Novartis Pharmaceuticals

Zurich University, Swiss National Science Foundation, Novartis Pharmaceuticals Study on the short-term efficacy (5 days) of everolimus (Votubia on the Swiss market) on the size of the infarction, the scarring of the left ventricle and the inflammation compared to placebo in patients hospitalized with a myocardial infarction.

Active sites in Switzerland: HUG, CHUV, Inselspital, Basel, Liestal
Expected duration of the study : ~ 2 years
Start in Geneva: January 2021
Property: Novartis Pharmaceuticals
Resp GEcor/HUG: Pr François MACH, Pr. Georg EHRET

Trial to evaluate the safety, tolerability and efficacy of inclisiran in adolescents (12 to less than 18 years of age) with familial hypercholesterolemia and high cholesterol (LDL-C).

International study
Expected duration of the study : ~ 5 years
Start in Geneva: August 2021
Property: NYU Langone Health
Resp GEcor/HUG: Pr François MACH, Dr. Quentin CHATELAIN

Randomized factorial 2×2 controlled trial to test the efficacy of colchicine and spironolactone on the incidence of CV events in patients with myocardial infarction and stented .

Swiss study
Expected duration of the study : ~ 14 years
Start in Geneva: 2011
Property: University Hospital Inselspital, Bern
Resp GEcor/HUG: Pr François MACH

National registry of patients with a TAVI (Transcatheter Aortic Valve Implantation).

International study
Study start : September 2020
Expected duration: 52 weeks
End of study: February 2022
Property: Bayer
Resp GEcor/HUG: Pr François MACH, Dr Juan F. IGLESIAS

Efficacy/safety evaluation study of BAY 2433334 (coagulation factor XI inhibitor. ) in patients with acute myocardial infarction, at increased risk of thrombosis, treated with double platelet anti-aggregation.

International study
Study start : 2016
Property: Population Health Research Institute (CA), Pfitzer, Medtronic, Bristol- Myers Squibb, Canadian Institutes of Health Research.
Resp GEcor/HUG: Pr Haran BURRI

Clinical study comparing the effects of aspirin and the anticoagulant Apixaban and evaluating the incidence of stroke and systemic embolism in patients with atrial fibrillation.

Local study (HUG)
Study start : April 2021
Expected duration : 2 years
End of study: June 2023
Property: HUG
Resp GEcor/HUG: Dr Elise BAKELANTS, Pr Haran BURRI

Comparison of two pacing methods on cardiac function and quality of life. Namely, the pacemaker or the internal defibrillator with a lead positioned on the His bundle.

International study
Study start : April 2021
Expected duration : 1 to 5 years
Property: University of Chicago, Biotronik SE & Co. KG
Resp GEcor/HUG: Pr Haran BURRI

Collecting information on routine clinical practices and devices used to treat cardiac rhythm disorders.

EU-Japan Collaboration
Study start : November 2019
Property/Sponsor: Terumo Europe N.V.
Resp GEcor/HUG: Dr Juan F. IGLESIAS

Study with the objective of demonstrating the superiority of the DTRA (Distal Radial Access) system over the CTRA (Conventional Transradial Access) system in cases of radial artery occlusion of the forearm.

International study
Study start :2022
Expected duration: 5 years
Property: Swissheart
Resp GEcor/HUG: Pr François MACH, Dr David Carballo

Creation of diagnostic scores and cardiovascular risks thanks to machine learning. Calculated on the basis of data from patients with acute heart failure (AHF), or acute coronary syndrome (ACS).

Participation in the European Register
Study start :2021
Property: HUG
Study completion : July 31, 2021
Resp GEcor/HUG: Pr François MACH, Dr Elena TESSITORE

Retrospective observational study to compare the short-, medium- and long-term prognoses and consequences of SARS-CoV-2 infections in hospitalized patients with or without pre-existing cardiovascular disease.

Swiss Register
Start of study :2020
Property: HUG
Resp GEcor/HUG: Pr François MACH, Dr David Carballo

Study of the effects of SARS-COV-2 infection in patients hospitalized for acute cardiac pathology.

Swiss Register, Biobank
Start of study :2014
Expected duration : 10 years
Property : UZH
Resp GEcor/HUG: Pr Haran BURRI

ARVC for “Arrhythmogenic Right Ventricular Cardiomyopathy”
Determination of clinical and genetic factors in patients with arrhythmogenic right ventricular cardiomyopathy (ADVC).